BIOC0030 Advanced molecular biology of protein regulatory networks Aim: To provide an appreciation of current scientific research in regulatory molecular networks through genetic engineering in cell-based and animal models. The course will concentrate on (a) covering the latest advances in our understanding of regulatory interactions in signaling and metabolic pathways; (b) exploring diverse experimental models for better understanding the function of individual proteins and multienzyme regulatory complexes. Topics covered: Advanced understanding of: a) molecular mechanisms of gene expression at the level of transcription, epigenetic regulation and translation b) posttranslational modifications and protein-protein interaction domains in signal transduction; d) signalling and metabolic regulatory networks in health and pathology. The use of cell-based (cell cultures, S. cerevisiae) and animal models (C. elegans, D. melanogaster, Zebrafish and mice) for gaining a better understanding of physiological processes and their deregulation in human pathologies, identifying new targets for drug discovery and development of novel diagnostic and therapeutic approaches. 0.5 course unit, term 1 Assessment: 80% on final exam (May/June 2021, 20% coursework test (Nov-Dec 2020)